NMN Studies

Clinical studies

Studies in humans to assess safety, efficacy, and optimal dosages of new treatments or interventions, often conducted in multiple phases.

Date Title Scientific Journal

Date 2025

Title Oral Supplementation of Nicotinamide Mononucleotide (NMN) Improves Hair Quality and Subjective Perception of Hair Appearance in Middle-Aged Women

Scientific Journal Single-arm, pre-post human clinical study (middle-aged women)

Date 2025

Title Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink (NMN-MeABD)

Scientific Journal Randomized, double-blind, crossover trial (metabolic endpoints)

Date 2024

Title Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Scientific Journal Clinical Study

Date 2024

Title Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD⁺) concentration

Scientific Journal Clinical Study

Date 2023

Title The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial

Scientific Journal Randomized, placebo-controlled dose-ranging clinical trial

Date 2023

Title Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

Scientific Journal Clinical Study

Date 2023

Title Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial

Scientific Journal Randomized clinical trial (12 weeks)

Date 2022

Title Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men.

Scientific Journal Clinical Study

Date 2022

Title Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Scientific Journal Clinical Study

Date 2022

Title Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

Scientific Journal Clinical Study

Date 2022

Title NAD⁺ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Scientific Journal Clinical trial registry (hypertension/vascular function)

Date 2022

Title A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adult

Scientific Journal Clinical Study

Date 2022

Title Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study

Scientific Journal Clinical Study

Date 2022

Title MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and Its Metabolome in Middle-Aged and Older Adults.

Scientific Journal Clinical Study

Date 2022

Title Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Scientific Journal Pilot clinical study / open-label or small randomized cohorts

Date 2021

Title Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function (NMN)

Scientific Journal Clinical trial registry (metabolic endpoints)

Date 2021

Title Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Scientific Journal Clinical Study

Date 2020

Title Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

Scientific Journal Clinical Study

Pre-clinical studies

Lab experiments conducted to evaluate safety, efficacy, and mechanisms of new treatments before human trials.

Date Title Scientific Journal

Date 2025

Title Oral nicotinamide mononucleotide (NMN) increases tissue NAD⁺ content in mice but neither NMN nor Polypodium leucotomos protect against UVR-induced skin cancer

Scientific Journal In vivo

Date 2025

Title NAD⁺ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

Scientific Journal In vivo

Date 2025

Title Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions

Scientific Journal In vitro / In vivo

Date 2025

Title Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice

Scientific Journal In vitro

Date 2025

Title Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in db/db Mice

Scientific Journal In vivo

Date 2025

Title Nicotinamide mononucleotide restores impaired metabolism, endothelial cell proliferation and angiogenesis in old sedentary male mice

Scientific Journal In vivo

Date 2025

Title NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway.

Scientific Journal In vivo / In vitro

Date 2025

Title NAD⁺ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Scientific Journal In vitro / In vivo

Date 2024

Title Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes.

Scientific Journal In vitro

Date 2024

Title Toxicology study profile of Nicotinamide mononucleotide after acute and 90-day sub chronic dosing in Wistar rats and mutagenicity tests

Scientific Journal In vitro / In vivo

Date 2024

Title Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

Scientific Journal In vivo

Date 2024

Title Absolute Quantification of Nicotinamide Mononucleotide in Biological Samples by Double Isotope-Mediated Liquid Chromatography-Tandem Mass Spectrometry (dimeLC-MS/MS)

Scientific Journal In vitro

Date 2024

Title Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway

Scientific Journal In vivo / In vitro

Date 2024

Title β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice.

Scientific Journal In vivo

Date 2024

Title Fertility protection during chemotherapy treatment by boosting the NAD(P)⁺ metabolome

Scientific Journal In vivo

Date 2023

Title NAD⁺ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Scientific Journal In vivo / Clinical study

Date 2023

Title Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD⁺ Biosynthesis in Whole Mice.

Scientific Journal In vivo

Date 2023

Title β-Nicotinamide mononucleotide activates NAD⁺/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice

Scientific Journal In vivo

Date 2023

Title Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis

Scientific Journal In vitro / In vivo

Date 2023

Title Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation

Scientific Journal In vivo

Date 2023

Title Nicotinamide mononucleotide ameliorates sleep deprivation-induced gut microbiota dysbiosis and restores colonization resistance against intestinal infections.

Scientific Journal In vivo

Date 2022

Title Nicotinamide mononucleotide attenuates ischemia-reperfusion injury induced by donor liver from cardiac death through Sirt3.

Scientific Journal In vivo

Date 2022

Title Nicotinamide mononucleotide administration restores redox homeostasis via the Sirt3-Nrf2 axis and protects aged mice from oxidative stress-induced liver injury.

Scientific Journal In vivo

Date 2022

Title Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

Scientific Journal In vitro / In vivo

Date 2022

Title Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD⁺ consumers mediated by Twist2

Scientific Journal In vivo

Date 2022

Title Nicotinamide mononucleotide administration amends protein acetylome of aged mouse liver.

Scientific Journal In vivo

Date 2022

Title Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.

Scientific Journal In vitro / In vivo

Date 2022

Title Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

Scientific Journal In vivo

Date 2022

Title Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells.

Scientific Journal In vitro / In vivo

Date 2022

Title Treatment of inflammatory bowel disease: potential effect of NMN on intestinal barrier and gut microbiota.

Scientific Journal In vivo

Date 2022

Title A rise in NAD⁺ precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration.

Scientific Journal In vivo

Date 2021

Title NMN maintains intestinal homeostasis by regulating the gut microbiota.

Scientific Journal In vivo

Date 2021

Title The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

Scientific Journal In vivo / Exploratory human study

Date 2021

Title Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE2 degradation.

Scientific Journal In vitro / In vivo

Date 2021

Title Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

Scientific Journal In vivo

Date 2021

Title Nicotinamide mononucleotide prevents cisplatin-induced mitochondrial defects in cortical neurons derived from human iPSCs

Scientific Journal In vitro / In vivo

Date 2020

Title Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: : transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Scientific Journal In vivo

Date 2020

Title Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.

Scientific Journal In vitro / In vivo

Date 2020

Title NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging

Scientific Journal In vivo

Date 2020

Title Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration

Scientific Journal In vivo

Date 2020

Title Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Scientific Journal In vivo

Date 2020

Title NAD⁺ precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms

Scientific Journal In vivo

Date 2020

Title Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

Scientific Journal In vivo

Date 2020

Title NAD⁺ precursors protect corneal endothelial cells from UVB-induced apoptosis

Scientific Journal In vitro / In vivo

Date 2019

Title Slc12a8 is a nicotinamide mononucleotide transporter

Scientific Journal In vivo / In vitro

Date 2019

Title Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.

Scientific Journal In vivo

Date 2019

Title Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Scientific Journal In vivo

Date 2019

Title Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Scientific Journal In vivo

Date 2019

Title Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death

Scientific Journal In vitro / In vivo

Date 2019

Title Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.

Scientific Journal In vivo

Date 2018

Title Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

Scientific Journal Ex vivo

Date 2017

Title Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure

Scientific Journal In vivo / In vitro

Date 2017

Title Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

Scientific Journal In vivo

Date 2017

Title Nicotinamide Mononucleotide, an NAD⁺ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

Scientific Journal In vitro / In vivo

Date 2017

Title Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

Scientific Journal In vivo

Date 2017

Title Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model

Scientific Journal In vivo

Date 2017

Title NMN deamidase delays wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo.

Scientific Journal In vivo

Date 2016

Title Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Scientific Journal In vivo

Date 2016

Title Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Scientific Journal In vivo

Date 2016

Title NAMPT-Mediated NAD⁺ Biosynthesis Is Essential for Vision In Mice

Scientific Journal In vivo

Date 2016

Title NAMPT-Mediated NAD⁺ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

Scientific Journal In vivo

Date 2016

Title Nicotinamide mononucleotide inhibits post-ischemic NAD⁺ degradation and dramatically ameliorates brain damage following global cerebral ischemia

Scientific Journal In vivo

Date 2015

Title SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD⁺ and Function in Mice.

Scientific Journal In vitro / In vivo / Ex vivo

Date 2015

Title Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1rd8/rd8) versus C57BL6/J (Crb1wt/wt) mice.

Scientific Journal In vivo

Date 2015

Title Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

Scientific Journal In vitro / Ex vivo

Date 2014

Title Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Scientific Journal In vivo / In vitro

Date 2014

Title Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease.

Scientific Journal In vitro

Date 2014

Title SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Scientific Journal In vivo

Date 2014

Title Nicotinamide mononucleotide, an intermediate of NAD⁺ synthesis, protects the heart from ischemia and reperfusion

Scientific Journal In vitro

Date 2013

Title Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

Scientific Journal In vivo

Date 2013

Title Administration of Nicotinamide Does Not Increase Platelet Levels in Mice

Scientific Journal In vitro / In vivo

Date 2013

Title Declining NAD⁺ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Scientific Journal In vivo

Date 2013

Title Circadian clock NAD⁺ cycle drives mitochondrial oxidative metabolism in mice.

Scientific Journal In vivo

Date 2011

Title Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma.

Scientific Journal In vitro / Ex vivo

Date 2009

Title Lack of Carcinogenicity of Nicotinamide and Isonicotinamide Following Lifelong Administration to Mice.

Scientific Journal In vivo

Date 2009

Title Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo

Scientific Journal In vitro / In vivo

Date 2007

Title Age-Associated Loss of Sirt1-Mediated Enhancement of Glucose-Stimulated Insulin Secretion in Beta Cell-Specific Sirt1-Overexpressing (BESTO) Mice.

Scientific Journal In vivo

Date 2007

Title Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD⁺ Biosynthetic Enzyme.

Scientific Journal In vivo

Date 2006

Title Tissue-Specific Regulation of Sirtuin and Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Identified in C57Bl/6 Mice in Response to High-Fat Feeding.

Scientific Journal In vivo

NMN Studies

Clinical studies

Pre-clinical studies

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